The p21 dependent G2 arrest of the cell cycle in epithelial tubular cells links to the early stage of renal fibrosis
T. Koyano, M. Namba, T. Kobayashi, K. Nakakuni, D. Nakano, M. Fukushima, A. Nishiyama, M. Matsuyama
The paper identifies p21-dependent G2 cell cycle arrest in proximal tubular cells as an early response to renal damage, which may protect kidney function during the initial stage of fibrosis.
bioRxiv · Feb 26, 2019Cell Biology