M. Matsuyama

Development of novel cytoprotective small compounds inhibiting mitochondria-dependent apoptosis

The paper identifies and develops M109S, a small molecule that inhibits mitochondria-dependent apoptosis in various cell types and models.

Functionally conserved Pkd2, mutated in autosomal dominant polycystic kidney disease, localizes to the endoplasmic reticulum and regulates cytoplasmic calcium homeostasis in fission yeast

This study shows that Pkd2, a homolog of human polycystin-2, localizes to the ER and regulates calcium homeostasis in fission yeast, with functional conservation between species.

LRRC23 is a conserved component of the radial spoke that is necessary for sperm motility and male fertility in mice

This study identifies LRRC23 as a conserved component of the radial spoke complex in mouse sperm, essential for flagellar motility and male fertility but not ciliary function.

Creation of X-linked Alport Syndrome Rat Model with Col4a5 Deficiency

This study creates a novel Alport syndrome rat model with Col4a5 deficiency to better understand renal disease mechanisms and therapeutic targets.

The p21 dependent G2 arrest of the cell cycle in epithelial tubular cells links to the early stage of renal fibrosis

The paper identifies p21-dependent G2 cell cycle arrest in proximal tubular cells as an early response to renal damage, which may protect kidney function during the initial stage of fibrosis.