Epigallocatechin-3-gallate inhibit the protein arginine methyltransferase 5 and Enhancer of Zeste homolog 2 in breast cancer both in vitro and in vivo
K. Nalla, B. Chatterjee, J. Poyya, A. Swain, K. Ghosh, A. Pan, C. G. Joshi, B. Manavathi, S. R. Kanade
This study shows that EGCG inhibits PRMT5 and EZH2 in breast cancer cells and xenografts, reducing histone repressive marks and inducing apoptosis and autophagy.
bioRxiv · Feb 18, 2024 · PreprintCancer Biology