A. Swain

Ellagic acid: a potential inhibitor of enhancer of zeste homolog-2 and protein arginine methyltransferase-5

This study identifies ellagic acid as an inhibitor of EZH2 and PRMT5:MEP50, showing reduced histone modifications and tumor growth in mouse models.

Epigallocatechin-3-gallate inhibit the protein arginine methyltransferase 5 and Enhancer of Zeste homolog 2 in breast cancer both in vitro and in vivo

This study shows that EGCG inhibits PRMT5 and EZH2 in breast cancer cells and xenografts, reducing histone repressive marks and inducing apoptosis and autophagy.

IL-15 priming alters IFN-γ regulation in murine NK cells

This study shows that IL-15 priming changes IFN-γ regulation in murine NK cells by altering transcriptional responses to activating receptor stimulation.

Autophagy protects against high-dose Mycobacterium tuberculosis infection

This study shows autophagy in myeloid cells protects against high-dose Mycobacterium tuberculosis infection by limiting myeloid-derived suppressor cells and promoting T cell responses, distinct from its role in low-dose infection.

Sampling bias and the robustness of ecological metrics for plant-damage-type association networks

The paper assesses how sampling bias affects ecological metrics in plant-damage-type association networks and identifies sampling thresholds for robustness.

Single-cell RNA transcriptome analysis reveals CXCL16/CXCR6 as maintenance factors for CNS tissue resident T cells that drive synapse elimination during viral recovery

Myeloid cell interferon responses correlate with clearance of SARS-CoV-2

This study uses longitudinal single-cell RNA sequencing in rhesus macaques to show that myeloid cell interferon responses correlate with SARS-CoV-2 clearance.

Lung epithelial signaling mediates early vaccine-induced CD4+ T cell activation and Mtb control

This study identifies lung epithelial signaling as critical for early vaccine-induced CD4+ T cell activation and Mtb control in BCG vaccinated hosts.

Interactions and information: Exploring task allocation in ant colonies using network analysis

The paper analyzes interaction networks in ant colonies to understand how task allocation and switching are influenced by network structure and information flow.

Animal soundscapes reveal key markers of Amazon forest degradation from fire and logging

This study uses soundscapes to identify markers of Amazon forest degradation from fire and logging, finding that acoustic patterns change significantly after multiple fires but less so after logging.

PKA drives paracrine crisis and WNT4-dependent testis tumor in Carney complex

The paper investigates the role of PKA in Carney complex testis tumors, showing that Prkar1a mutations in both stromal and Sertoli cells drive LCCSCTs via WNT4-dependent paracrine signaling.

Effects of substrate availability on growth and metabolism in soil microbes: Insights from theoretical modeling of studies of the Warburg effect and substrate-induced respiration

The paper models microbial respiration responses to substrate availability using a Warburg effect framework and validates predictions with substrate-induced respiration experiments.

Deciphering trophic interactions in a mid-Cambrian assemblage

The paper presents a high-resolution Cambrian fossil dataset and a new preservation bias measure to analyze trophic interactions using network science, finding a shift from specialist to generalist interactions.

A mouse SWATH-MS reference spectral library enables deconvolution of species-specific proteomic alterations in human tumour xenografts

The paper develops a mouse SWATH-MS spectral library and a deconvolution method to analyze proteomic changes in human tumor xenografts, revealing host-tumor interactions.

Effect of ring topology in a stochastic model for Z-ring dynamics in bacteria

This study presents a stochastic model of Z-ring dynamics in bacteria, showing that ring breaking and hydrolysis induce rescue and catastrophe events, leading to random breaking and closing of the Z-ring during cell division.

Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance

The paper identifies PARP1 point mutations causing PARP inhibitor resistance through CRISPR-Cas9 screens and shows their impact on PARP1 trapping and chemotherapy sensitivity.