K. Ghosh

Ellagic acid: a potential inhibitor of enhancer of zeste homolog-2 and protein arginine methyltransferase-5

This study identifies ellagic acid as an inhibitor of EZH2 and PRMT5:MEP50, showing reduced histone modifications and tumor growth in mouse models.

PATHOGEN GROWTH AND VIRULENCE DYNAMICS DRIVE THE HOST EVOLUTION AGAINST COINFECTIONS

This study shows that host evolution against coinfections is influenced by the growth and virulence dynamics of individual pathogens, with fast-acting pathogens hindering adaptive success.

Stiffness Measurement of Retinal Capillaries and Subendothelial Matrix using Atomic Force Microscopy

The paper provides a protocol for measuring retinal capillary and subendothelial matrix stiffness in mice using atomic force microscopy.

Epigallocatechin-3-gallate inhibit the protein arginine methyltransferase 5 and Enhancer of Zeste homolog 2 in breast cancer both in vitro and in vivo

This study shows that EGCG inhibits PRMT5 and EZH2 in breast cancer cells and xenografts, reducing histone repressive marks and inducing apoptosis and autophagy.

Experimental evolution of Pseudomonas aeruginosa to colistin in spatially confined microdroplets identifies evolutionary trajectories consistent with adaptation in microaerobic lung environments

This study uses microdroplet emulsions to simulate CF lung microenvironments and identifies evolutionary trajectories of Pseudomonas aeruginosa to colistin resistance, showing that PhoP/PhoQ pathway mutations are favored in microaerobic conditions.

Mechanical regulation of retinal vascular inflammation and degeneration in diabetic retinopathy

This study shows that retinal vascular stiffening, caused by LOX overexpression, mechanically regulates inflammation and degeneration in diabetic retinopathy, and that inhibiting LOX prevents these effects.

Lysyl oxidase-dependent subendothelial matrix stiffening promotes RAGE-mediated retinal endothelial activation in diabetes

This study shows that LOX-dependent matrix stiffening, regulated by RAGE, promotes retinal endothelial activation in diabetes, suggesting new therapeutic targets for diabetic retinopathy.

Cell Stiffening Contributes to Complement-mediated Injury of Choroidal Endothelial Cells in Early AMD

This study shows that cell stiffness and cytoskeletal regulators Rac and Rho influence complement-mediated injury in choroidal endothelial cells in early AMD.

Leaf Aqueous Extract of Manilkara hexandra influenced Glucose Metabolism in fish: An observation with Labeo rohita Fingerlings as model organism

This study investigates the hypoglycaemic effect of Manilkara hexandra leaf extract on glucose metabolism in Labeo rohita fingerlings by analyzing enzyme activities and serum glucose levels.

A toxin-antitoxin system associated transcription factor of Caulobacter crescentus can influence cell cycle-regulated gene expression during the SOS response

This paper investigates the role of the HigBA toxin-antitoxin system in Caulobacter crescentus during the SOS response, revealing HigC's regulatory effects on cell cycle gene expression and antibiotic resistance.

The role of dermis resident macrophages and their interaction with neutrophils in the early establishment of Leishmania major infection transmitted by sand fly bite

This study investigates how dermis resident macrophages and neutrophils interact during early Leishmania major infection transmitted by sand fly bite, revealing the role of phagocytosis and receptor tyrosine kinases in infection outcomes.

Ancient Thioredoxins Evolved to Modern Day Stability-Function Requirement by Altering Native State Ensemble

The paper compares ancient and modern Thioredoxins to show how their native state ensemble properties evolved, affecting stability and function.