Active Translation Control of CD4 T Cell Activation by Regulatory T Cells
L. So, K. Obata-Ninomiya, A. Hu, V. Muir, A. Takamori, J. Song, J. H. Buckner, R. Savan, S. Ziegler
This study shows regulatory T cells suppress CD4 T cell activation by inhibiting translation of mRNAs encoding protein synthesis machinery, highlighting translational control in immune tolerance.
bioRxiv · Sep 23, 2021Immunology