Mouse model and human patient data suggest critical roles for Pten and p53 in suppressing POLE mutant tumor development
V. S. Park, M. J. Sun, W. D. Frey, L. G. Williams, K. P. Hodel, J. D. Strauss, S. J. Wellens, J. G. Jackson, Z. F. Pursell
The paper shows that Pten and p53 loss contribute to POLE mutant tumor growth, but not mutation burden, in mice and humans.
bioRxiv · Oct 10, 2021 · PreprintCancer Biology