Metabolic dysfunction induced by high-fat diet modulates hematopoietic stem and myeloid progenitor cells in brown adipose tissue of mice
K. T. Mincham, K. Panchal, P. H. Hart, R. M. Lucas, M. Feelisch, R. B. Weller, V. B. Matthews, D. H. Strickland, S. Gorman
This study examines how a high-fat diet affects hematopoietic stem and myeloid progenitor cells in brown adipose tissue and bone marrow of mice, finding reduced HSPC subsets and increased conventional DCs with metabolic dysfunction.
bioRxiv · Mar 2, 2021Cell Biology