Author

D. H. Strickland

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:mouse· 6 Research Focus:cell type annotation· 4 Research Focus:differential expression· 3 Research Focus:host-pathogen & immune response· 3 Assay:flow cytometry· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2

Frequent Co-Authors

K. T. Mincham· 5 shared P. G. Holt· 5 shared A. Bosco· 3 shared J.-F. Lauzon-Joset· 3 shared P. A. Stumbles· 3 shared J. F. Read· 2 shared N. M. Scott· 2 shared A. C. Jones· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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5 shared papersImmunology

K. T. Mincham

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Single cell transcriptomics reveals cell type specific features of developmentally regulated responses to lipopolysaccharide between birth and 5 years.

J. F. Read, M. Serralha, J. Armitage, M. M. Iqbal, M. N. Cruickshank, A. Saxena, D. H. Strickland, J. Waithman, P. G. Holt, A. Bosco

This study uses single cell RNA-sequencing to compare the transcriptional responses to LPS in cord blood and 5-year-old peripheral blood mononuclear cells, revealing developmental changes in immune cell signaling and communication.

Frontiers in Immunology · Oct 17, 2023Peer-reviewedImmunology

Mapping lung hematopoietic progenitors: Developmental kinetics and response to Influenza A viral infection

K. T. Mincham, J.-F. Lauzon-Joset, J. F. Read, P. G. Holt, P. A. Stumbles, D. H. Strickland

The paper identifies lung hematopoietic progenitors that change with age and respond to Influenza A infection by altering progenitor populations and immunological homeostasis.

bioRxiv · Oct 9, 2023Immunology

Early-life respiratory viral infection results in impairment of adult lung function

L. Harb, P. G. Holt, D. H. Strickland, D. Martino, A. N. Larcombe, A. Bosco

This study establishes a mouse model of early-life respiratory viral infection that leads to adult lung function impairment, showing sex-dependent effects and pathogen-specific outcomes.

bioRxiv · Sep 20, 2021 · PreprintImmunology

Protection against neonatal respiratory viral infection via maternal treatment during pregnancy with the benign immune training agent OM-85

J.-F. Lauzon-Joset, K. T. Mincham, N. M. Scott, Y. Khandan, P. A. Stumbles, P. G. Holt, D. H. Strickland

Maternal treatment with OM-85 during pregnancy enhances neonatal resistance to respiratory viral infection by accelerating immune maturation and improving lung immune responses.

bioRxiv · Mar 2, 2021Immunology

Metabolic dysfunction induced by high-fat diet modulates hematopoietic stem and myeloid progenitor cells in brown adipose tissue of mice

K. T. Mincham, K. Panchal, P. H. Hart, R. M. Lucas, M. Feelisch, R. B. Weller, V. B. Matthews, D. H. Strickland, S. Gorman

This study examines how a high-fat diet affects hematopoietic stem and myeloid progenitor cells in brown adipose tissue and bone marrow of mice, finding reduced HSPC subsets and increased conventional DCs with metabolic dysfunction.

bioRxiv · Mar 2, 2021Cell Biology

Transplacental innate immune training via maternal microbial exposure: a central role for the XBP1-ERN1 axis in programming dendritic cell precursors

K. T. Mincham, A. C. Jones, M. Bodinier, N. M. Scott, J.-F. Lauzon-Joset, P. A. Stumbles, A. Bosco, P. G. Holt, D. H. Strickland

This study identifies the XBP1-ERN1 axis as critical for maternal OM-85-induced immune training in fetal dendritic cell precursors, enhancing postnatal resistance to airway inflammation.

bioRxiv · May 15, 2020Immunology

High-Dimensional Immunophenotyping of Murine T-cell and B-cell Subsets

K. T. Mincham, J. D. Young, D. H. Strickland

The paper introduces a 19-parameter flow cytometry panel for comprehensive immunophenotyping of T-cell and B-cell subsets in murine lymphoid tissues.

bioRxiv · May 7, 2020 · PreprintCell Biology