J. J. Kim

De Novo TANGLED1 Recruitment to Aberrant Cell Plate Fusion Sites in Maize

The paper shows TANGLED1 is recruited to cell plate fusion sites independently of the preprophase band during cytokinesis in maize.

Empagliflozin reduces renal lipotoxicity in experimental Alport syndrome

This study shows empagliflozin reduces renal lipotoxicity and improves kidney function in experimental Alport syndrome by shifting energy substrates from glucose to fatty acids in podocytes.

Proteome-wide microarray-based screening of PAR-binding proteins

The paper identifies 356 PAR-binding proteins using a human protein microarray, revealing new biological roles of PARylation beyond DNA repair.

An auto-inhibited state of protein kinase G and implications for selective activation

This study presents crystal structures of PKG Iβ in auto-inhibited and activated states, revealing the mechanism of cGMP-mediated activation and isoform-specific regulation.

Endometriotic Organoids: A Novel In Vitro Model of Endometriotic Lesion Development.

This study develops endometriotic organoids to model epithelial-stromal interactions and cell invasion in endometriotic lesion development, finding increased invasion with estrogen or proinflammatory macrophages.

Prime-boost vaccination regimens with INO-4800 and INO-4802 augment and broaden immune responses against SARS-CoV-2 in nonhuman primates

Design, immunogenicity and efficacy of a Pan-SARS-CoV-2 synthetic DNA vaccine

This study designs and tests a DNA vaccine, INO-4802, which induces broad immunity against multiple SARS-CoV-2 variants in animal models.

INO-4800 DNA Vaccine Induces Neutralizing Antibodies and T cell Activity Against Global SARS-CoV-2 Variants

This study evaluates the efficacy of the INO-4800 DNA vaccine against SARS-CoV-2 variants, showing neutralizing antibodies and preserved T cell responses.

Molecular mechanism of ACAD9 in mitochondrial respiratory complex 1 assembly

This study investigates the molecular mechanism of ACAD9 in mitochondrial respiratory complex 1 assembly, revealing its dual role as a chaperone and its structural interactions with ECSIT and NDUFAF1.

Early-life mitochondrial DNA damage results in lifelong deficits in energy production mediated by redox signaling in Caenorhabditis elegans

This study shows that early-life mitochondrial DNA damage in C. elegans causes lifelong energy production deficits through redox signaling mechanisms.

Antimicrobial peptide induced-stress renders Staphylococcus aureus susceptible to toxic nucleoside analogues

The paper shows that sub-lethal concentrations of the antimicrobial peptide pexiganan increase susceptibility of Staphylococcus aureus to nucleoside analogues.

Intradermal-delivered DNA vaccine provides anamnestic protection in a rhesus macaque SARS-CoV-2 challenge model

This study evaluates an intradermal DNA vaccine against SARS-CoV-2 in rhesus macaques, showing it induces immune responses and provides protection against viral challenge.

S-MiRAGE: A quantitative, secreted RNA-based reporter of gene expression and cell persistence

S-MiRAGE uses secreted RNA to quantitatively track cell persistence and gene expression in vitro and in vivo.

CD55 regulates self-renewal and cisplatin resistance in endometrioid tumors

This study identifies CD55 as a signaling hub that regulates self-renewal and cisplatin resistance in endometrioid tumors through distinct signaling pathways.