Autotrophic adaptive laboratory evolution of the acetogen Clostridium autoethanogenum delivers the gas-fermenting strain LAbrini with superior growth, products, and robustness
H. Ingelman, J. K. Heffernan, A. Harris, S. D. Brown, K. M. Shaikh, A. Yar Saqib, M. J. Pinheiro, L. A. de Lima, K. Rodriguez Martinez, R. A. Gonzalez-Garcia, G. Hawkins, J. Daleiden, L. Tran, H. Zeleznik, R. O. Jensen, , K. Valgepea
This study evolves C. autoethanogenum through adaptive laboratory evolution to create a strain with faster growth, better product profile, and improved robustness in continuous cultures.
bioRxiv · Jan 28, 2023Bioengineering