A. Harris

The role of β-Nicotyrine in E-Cigarette abuse liability I: Drug Discrimination

This study examines β-Nicotyrine's effects on nicotine discrimination in rats, finding it prolongs nicotine's stimulus properties but does not fully substitute for nicotine.

IgM plays a prominent role in naturally acquired immunity against Plasmodium falciparum gametocytes

This study identifies IgM as a key antibody isotype in immune responses against Plasmodium falciparum gametocytes, showing its superior complement fixation activity compared to IgG.

Intra-species quantification reveals differences in activity and sleep levels in the yellow fever mosquito, Aedes aegypti

This study compares activity and sleep levels across 17 Ae. aegypti lines, finding population differences linked to host preference, ancestry, and human population density.

Imputation of ancient canid genomes reveals inbreeding history over the past 10,000 years

This study imputes ancient dog and wolf genomes to analyze inbreeding history over 10,000 years, finding lower inbreeding in ancient populations and associations between low ROH regions and olfaction/immune genes.

Autotrophic adaptive laboratory evolution of the acetogen Clostridium autoethanogenum delivers the gas-fermenting strain LAbrini with superior growth, products, and robustness

This study evolves C. autoethanogenum through adaptive laboratory evolution to create a strain with faster growth, better product profile, and improved robustness in continuous cultures.

Rupture Strength of Living Cell Monolayers

This study investigates how epithelial monolayers withstand mechanical stress and rupture, showing that keratin filaments control strain stiffening and tissue strength.

A genomic timescale for placental mammal evolution

This study constructs a genomic timescale for placental mammal evolution using whole genome phylogenies, revealing timing and patterns of ordinal diversification.

Dietary inclusion of nitrite-containing frankfurter exacerbates colorectal cancer pathology, alters metabolism and causes gut dybiosis in APCmin mice

This study shows that feeding APCmin mice nitrite-containing frankfurter increases gastrointestinal tumors, lipid peroxidation, and gut dysbiosis compared to nitrite-free diets.

A new twist in ABC transporter mediated multidrug resistance - Pdr5 is a drug/proton co-transporter

This study shows Pdr5, an ABC transporter, functions as a proton/drug co-transporter, generating a proton motive force during drug efflux, suggesting a more complex mechanism of multidrug resistance.

Structure and efflux mechanism of the yeast pleiotropic drug resistance transporter Pdr5

This study reveals the structural and functional mechanism of the yeast Pdr5 transporter, showing how it uses ATP to drive drug efflux through a conformational cycle and an amphipathic channel.

Free energy and kinetics of cAMP permeation through connexin26 hemichannel with and without voltage

This study investigates the free energy and kinetics of cAMP permeation through connexin26 hemichannels using simulations, revealing binding sites, directional transition rates, and the role of voltage and ions.

Tumor irradiation combined with vascular-targeted photodynamic therapy enhances anti-tumor effects in preclinical prostate cancer.

This paper investigates combining fractionated radiotherapy with vascular-targeted photodynamic therapy to enhance tumor control in preclinical prostate cancer models.

Biofluid modeling of the coupled eye-brain system and insights into simulated microgravity conditions

This paper models fluid dynamics in the eye-brain system under microgravity to explain visual impairment in astronauts, finding increased pressures and altered blood flow patterns.

BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors

This study shows that BRCA2 loss in cancer cells triggers innate immune responses, which are enhanced by PARP inhibitors, suggesting a mechanism for their therapeutic effect.