Author

S. D. Brown

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Bioengineering· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:bulk RNA-seq· 1 Organism:C. elegans· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:clustering· 1

Frequent Co-Authors

R. A. Holt· 3 shared C. M. Rive· 2 shared E. Yung· 2 shared L. Dreolini· 2 shared A. Harris· 1 shared A. Parker· 1 shared A. Shams· 1 shared A. V. Robinson· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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3 shared papersImmunology

R. A. Holt

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Autotrophic adaptive laboratory evolution of the acetogen Clostridium autoethanogenum delivers the gas-fermenting strain LAbrini with superior growth, products, and robustness

H. Ingelman, J. K. Heffernan, A. Harris, S. D. Brown, K. M. Shaikh, A. Yar Saqib, M. J. Pinheiro, L. A. de Lima, K. Rodriguez Martinez, R. A. Gonzalez-Garcia, G. Hawkins, J. Daleiden, L. Tran, H. Zeleznik, R. O. Jensen, , K. Valgepea

This study evolves C. autoethanogenum through adaptive laboratory evolution to create a strain with faster growth, better product profile, and improved robustness in continuous cultures.

bioRxiv · Jan 28, 2023Bioengineering

Myosin-driven Nucleation of Actin Filaments Drives Stereocilia Development Critical for Hearing

Z. G. Moreland, F. Jiang, C. Aguilar, M. Barzik, R. Gong, A. Shams, C. Faaborg-Andersen, J. C. Werth, R. Harley, D. C. Sutton, S. M. Cole, A. Parker, S. Morse, E. Wilson, Y. Takagi, , J. E. Bird

This study identifies a mutation in MYO15 that disrupts actin nucleation at stereocilia tips, causing hearing loss by impairing stereocilia growth.

bioRxiv · Jul 9, 2021 · PreprintCell Biology

Invasion by Fusobacterium nucleatum Causes Upregulation of dll4 and klf4 Expression in Caco-2 Cells

E. Allen-Vercoe, K. Cochrane, A. V. Robinson, J. Powers, S. D. Brown, R. A. Holt

The paper investigates how invasive Fusobacterium nucleatum strains upregulate host genes dll4 and klf4 in Caco-2 cells compared to a non-invasive E. coli control.

bioRxiv · Oct 26, 2020 · PreprintCancer Biology

Recombinant T cell receptors specific for HLA-A*02:01-restricted neoepitopes containing KRAS codon 12 hotspot mutations

C. M. Rive, E. Yung, C. S. Hughes, S. D. Brown, G. Sharma, L. Dreolini, N. M. Mawji, C. Warren, J. Karasinska, J. M. Loree, D. T. Yapp, G. B. Morin, D. J. Renouf, D. F. Schaeffer, S. Turcotte, R. A. Holt

The paper identifies and characterizes T cell receptors specific for HLA-A*02:01-restricted KRAS codon 12 mutations in cancer, showing their reactivity and cytotoxic activity against tumor cells.

bioRxiv · Jun 15, 2020 · PreprintImmunology

Selective B cell depletion upon intravenous infusion of replication-incompetent anti-CD19 CAR lentivirus

C. M. Rive, E. Yung, L. Dreolini, S. D. Brown, C. G. May, D. J. Woodsworth, R. A. Holt

This study shows that IV infusion of anti-CD19 CAR lentiviral vectors leads to persistent CAR-T cell expansion and complete B cell depletion in mice.

bioRxiv · May 15, 2020Immunology