Microglia at Sites of Atrophy Restrict the Progression of Retinal Degeneration via Galectin-3 and Trem2 Interactions
C. Yu, E. M. Lad, R. Mathew, S. Littleton, Y. Chen, K. Schlepckow, S. Degan, L. Chew, J. Amason, J. Kalnitsky, C. Bowes Rickman, A. D. Proia, M. Colonna, C. Haass, D. Saban
The paper identifies a common neuroprotective response of microglia at retinal atrophy sites in mice and humans, mediated by galectin-3 and Trem2 interactions.
bioRxiv · Jul 19, 2023Immunology