A. Hladik

Nuclear receptor corepressor 1 controls regulatory T cell subset differentiation and effector function

This study shows NCOR1 regulates Treg cell differentiation and suppressive function by maintaining transcriptional integrity in both naive and effector states.

TREM2 limits necrotic core formation during atherogenesis by controlling macrophage survival and efferocytosis

This study shows TREM2 deficiency increases necrotic core formation in atherosclerosis by impairing macrophage efferocytosis and survival.

A neutrophil-B-cell axis governs disease tolerance during sepsis via Cxcr4

This study identifies a neutrophil-B-cell axis that promotes disease tolerance during sepsis through Cxcr4 activation, reducing organ damage and immunothrombosis.

Development of a novel, pan-variant aerosol intervention for COVID-19

This paper reports preclinical development and evaluation of aerosolized soluble recombinant human ACE2 (APN01) as a COVID-19 intervention.

ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathology

This paper develops a mouse-adapted SARS-CoV-2 strain, maVie16, to model COVID-19 in mice, showing that ACE2 is critical for disease and that blocking TNF/IFNγ reduces immunopathology.

Murine ex vivo cultured alveolar macrophages provide a novel tool to study tissue-resident macrophage behavior and function

This paper introduces a method to culture and expand murine alveolar macrophages ex vivo over several months, showing they retain key features and functions.