A widely distributed gene cluster compensates for uricase loss in hominids
Y. Liu, J. B. Jarman, Y. S. Low, S. Huang, H. Chen, M. E. Defeo, K. Sekiba, B.-H. Hou, C. Ganesan, A. C. Pao, S. Gombar, D. Dodd
The paper identifies a bacterial gene cluster that compensates for human uricase loss by degrading uric acid in the gut, linking gut microbiota to hyperuricemia and gout risk.
bioRxiv · Jul 24, 2022Microbiology