MHC-matched allogeneic bone marrow transplant fails to eliminate SHIV-infected cells from ART-suppressed Mauritian cynomolgus macaques
J. T. Weinfurter, S. S. D'Souza, L. M. Matschke, S. Bennett, L. E. Kelnhofer-Millevolte, K. Suknuntha, A. Kumar, J. Coonen, C. M. Capitini, P. Hematti, T. G. Golos, I. I. Slukvin, M. R. Reynolds
This study shows that MHC-matched allogeneic bone marrow transplants in ART-suppressed SHIV-infected macaques do not fully eliminate viral reservoirs, with persistent SHIV DNA in tissues and rebound after ART interruption.
bioRxiv · Apr 16, 2021 · PreprintImmunology