In utero estrogenic endocrine disruption alters the stroma to increase extracellular matrix density and mammary gland stiffness.
C. Wormsbaecher, A. R. Hindman, A. Avendano, M. Cortes, A. Bushman, L. Onua, C. E. Kovalchin, A. R. Murphy, H. L. Helber, A. Shapiro, K. Voytovitch, X. Kuang, J. W. Song, C. J. Burd
This study shows that in utero exposure to estrogenic endocrine disruptors like BPA increases mammary gland stiffness and extracellular matrix density in adult mice, linking early-life exposure to increased breast cancer risk.
bioRxiv · Aug 30, 2019Cancer Biology