Author

C. J. Burd

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cancer & tumor microenvironment· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

B. M. Murphy· 3 shared C. E. Burd· 3 shared T. J. Weiss· 2 shared A. Avendano· 1 shared A. Bushman· 1 shared A. Dhakal· 1 shared A. H. Shain· 1 shared A. M. Holderbaum· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersCancer Biology

B. M. Murphy

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Author profile →

5 papers

Recent·Most cited

The OSUMMER lines: a series of ultraviolet-accelerated NRAS-mutant mouse melanoma cell lines syngeneic to C57BL/6

B. M. Murphy, D. M. Jensen, T. E. Arnold, R. Aguilar Valenzuela, J. Hughes, V. Posada, K. T. Nguyen, V. T. Chu, K. Y. Tsai, C. J. Burd, C. E. Burd

The paper introduces a series of NRAS-mutant melanoma cell lines derived from UV-exposed mice to model human melanoma resistance and therapy responses.

Pigment Cell & Melanoma Research · Sep 1, 2023Peer-reviewedCancer Biology

Functional differences drive the selection of NRAS mutants in melanoma

B. M. Murphy, T. J. Weiss, A. M. Holderbaum, A. Dhakal, M. Fort, M. S. Bodnar, M. Chen, C. J. Burd, V. COPPOLA, C. E. Burd

This study shows that specific NRAS mutants drive melanoma formation in mice, with Q61R and Q61K being the most effective, while others like G12D or Q61Q are not.

bioRxiv · Jan 15, 2021 · PreprintCancer Biology

UVB mutagenesis differs in NRAS- and BRAF-mutant mouse models of melanoma

R. L. Bowman, R. C. Hennessey, D. A. Tallman, T. J. Weiss, E. R. Crawford, B. M. Murphy, A. Webb, S. Zhang, K. M. D. La Perle, C. J. Burd, R. L. Levine, A. H. Shain, C. E. Burd

This study compares UVB mutagenesis effects in NRAS- and BRAF-mutant mouse melanoma models, finding BRAF-mutant tumors have more mutations and a stronger UVB mutational signature.

bioRxiv · Dec 27, 2020 · PreprintCancer Biology

In utero estrogenic endocrine disruption alters the stroma to increase extracellular matrix density and mammary gland stiffness.

C. Wormsbaecher, A. R. Hindman, A. Avendano, M. Cortes, A. Bushman, L. Onua, C. E. Kovalchin, A. R. Murphy, H. L. Helber, A. Shapiro, K. Voytovitch, X. Kuang, J. W. Song, C. J. Burd

This study shows that in utero exposure to estrogenic endocrine disruptors like BPA increases mammary gland stiffness and extracellular matrix density in adult mice, linking early-life exposure to increased breast cancer risk.

bioRxiv · Aug 30, 2019Cancer Biology

GREB1 regulates proliferation of estrogen receptor positive breast cancer through modulation of PI3K/Akt/mTOR signaling

C. N. Haines, H. D. Klingensmith, C. J. Burd

This study identifies GREB1's role in regulating breast cancer proliferation via the PI3K/Akt/mTOR pathway by showing knockdown causes growth arrest and overexpression induces senescence.

bioRxiv · Jul 16, 2019 · PreprintCancer Biology