Recognition of RNA secondary structures with a programmable peptide nucleic acid-based platform
R. Lu, L. Deng, Y. Lian, X. Ke, L. Yang, K. Xi, A. A. L. Ong, Y. Chen, H. Zhou, Z. Meng, R. Lin, S. Fan, Y. Liu, D.-F. K. Toh, X. Zhan, , G. Chen
This paper introduces daPNAs, a programmable platform combining dbPNAs and asPNAs to target RNA junctions, demonstrating their use in inhibiting Dicer and regulating ribosomal frameshifting.
bioRxiv · May 14, 2024Biochemistry