X. Zhan

Enhanced Recognition of a Herbal Compound Epiberberine by a DNA Quadruplex-Duplex Structure

This paper investigates how epiberberine binds to a DNA quadruplex structure and shows how modifying the DNA structure enhances binding affinity, leading to a new method for extracting the compound from plant extracts.

Structural and Biophysical Dynamics of Fungal Plasma Membrane Proteins and Implications for Echinocandin Action in Candida glabrata

This study investigates the structural and dynamic organization of plasma membrane proteins in Candida glabrata using cryo-ET and live cell imaging, revealing how echinocandin drugs affect their distribution and function.

Recognition of RNA secondary structures with a programmable peptide nucleic acid-based platform

This paper introduces daPNAs, a programmable platform combining dbPNAs and asPNAs to target RNA junctions, demonstrating their use in inhibiting Dicer and regulating ribosomal frameshifting.

Susceptible bacteria survive antibiotic treatment in the mammalian gastrointestinal tract without evolving resistance

The paper shows that gut bacteria can survive antibiotic treatment without developing resistance by acquiring mutations that enhance their ability to persist and invade intestinal cells.

A Deep Learning Approach for Histology-Based Nuclei Segmentation and Tumor Microenvironment Characterization

This study introduces HD-Yolo, a deep learning method for faster and more accurate nuclei segmentation and tumor microenvironment quantification in whole-slide images.

Structural Insights into Branch Site Proofreading by Human Spliceosome

The paper reports atomic structures of human spliceosome complexes to elucidate PRP5's role in branch site proofreading during pre-mRNA splicing.

Mapping global land sharing-sparing patterns between human and wildlife

The paper maps global land sharing-sparing patterns between humans and wildlife using human-nature indices and classifies lands into four categories based on biodiversity and human pressure.

Near-atomic Structure of the Cytoplasmic Ring of the Xenopus laevis Nuclear Pore Complex

The paper presents near-atomic cryo-EM structures of the Xenopus laevis nuclear pore complex cytoplasmic ring, revealing its scaffold composition and organization.

Immune checkpoint blockade induces gut microbiota translocation that augments extraintestinal anti-tumor immunity

Immune checkpoint blockade therapy promotes gut microbiota translocation into secondary lymphoid organs, enhancing extraintestinal anti-tumor immunity.

Neutralization Fingerprinting Technology for Characterizing Polyclonal Antibody Responses to Dengue Vaccines

This study presents a computational framework to analyze neutralizing antibody specificities in response to dengue vaccines, revealing differences in immune responses based on prior infection status.

A Novel Oncogenic Function of PRC2 Heterogeneity in Medulloblastoma

This study shows that PRC2 heterogeneity in SHH medulloblastomas drives tumor growth through intrinsic and non-cell autonomous mechanisms involving IGF2.

Study of growth, metabolism, and morphology of Akkermansia muciniphila with an in vitro advanced bionic intestinal reactor

This study cultivates Akkermansia muciniphila in a dynamic bionic intestinal reactor with different media, finding higher biomass and specific metabolites under human mucin conditions.

Cryo-EM structure of the Inner Ring from Xenopus laevis Nuclear Pore Complex

The paper presents a cryo-EM structure of the inner ring subunit from Xenopus laevis NPC, revealing its composition and interactions.

Transcriptome innovations in primates revealed by single-molecule long-read sequencing

The paper uses long-read sequencing to identify novel transcripts and isoform changes in primate transcriptomes, highlighting immune-related regulatory divergence.

Severe fever with thrombocytopenia syndrome virus and parthenogenetic Asian longhorned tick Haemaphysalis longicornis (Acari: Ixodidae)

The paper investigates the role of parthenogenetic Asian longhorned ticks in spreading SFTSV, finding they contribute to rapid spread and long-range movement.

Structural mapping of antibody landscapes to human betacoronavirus spike proteins

The paper maps epitopes of polyclonal antibodies against beta-coronavirus spike proteins in human sera, revealing cross-reactive patterns between seasonal and SARS-2 infections.

Towards a comprehensive delineation of white matter tract-related deformation

This study introduces three new tract-related strain measures to improve concussion prediction in finite element head models by analyzing white matter deformation during impacts.

Mechanism of negative regulation of NF-κB by N4BP1

This study identifies N4BP1 as an inhibitor of NF-κB activation by interacting with NEMO, and shows that caspase 8 cleavage inactivates N4BP1 during TRIF-dependent signaling.

Limits to the cellular control of sequestered cryptophyte prey in the marine ciliate Mesodinium rubrum

This study investigates how the marine ciliate Mesodinium rubrum controls sequestered cryptophyte organelles, finding limited transcriptional control and significant gene expression from the prey.

Cryo-EM structure of C9ORF72-SMCR8-WDR41 reveals the role as a GAP for Rab8a and Rab11a

This paper reports the cryo-EM structure of the C9ORF72-SMCR8-WDR41 complex, revealing its role as a GAP for Rab8a and Rab11a.

On the origin and evolution of RNA editing in metazoans

The paper investigates the origin and evolution of A-to-I RNA editing in metazoans, finding it emerged in the common ancestor and is nonadaptive in most regions except for specific taxa.

Characterization of the Intestinal Absorption of Morroniside from Cornus officinalis Sieb. et Zucc via a Caco-2 Cell Monolayer Model

This study investigates the intestinal absorption of morroniside using a Caco-2 cell model, finding pH- and temperature-dependent transport and involvement of efflux proteins.

Loss of microbial diversity and body site heterogeneity in individuals with Hidradenitis Suppurativa

This study examines microbial diversity and skin niche heterogeneity in HS patients compared to healthy individuals, finding reduced diversity and altered metabolic pathways.

Structures of the Human Spliceosomes Before and After Release of the Ligated Exon

This study reports cryo-EM structures of two late-stage human spliceosomes, revealing insights into exon release and spliceosome disassembly mechanisms.