Z. Meng

Climate adaptation in P. trichocarpa: key adaptive loci identified for stomata and leaf traits

This study identifies key genetic loci associated with stomatal and leaf traits in Populus trichocarpa that contribute to climate adaptation, showing smaller stomata in genotypes from arid regions.

Recognition of RNA secondary structures with a programmable peptide nucleic acid-based platform

This paper introduces daPNAs, a programmable platform combining dbPNAs and asPNAs to target RNA junctions, demonstrating their use in inhibiting Dicer and regulating ribosomal frameshifting.

Gel-Assisted Proteome Position Integral Shift (GAPPIS) Assay Returns Molecular Weight to Shotgun Proteomics and Identifies Novel Caspase 3 Substrates

The paper introduces GAPPIS, a method to recover molecular weight information from shotgun proteomics, identifying novel caspase 3 substrates in apoptotic cells.

Do light eaters live shorter lives? The case of ultralight Caenorhabditis elegans

This study shows that ultralight Caenorhabditis elegans, grown on isotopically depleted bacteria, have shorter lifespans despite faster growth and maturation.

RNA Splicing Junction Landscape Reveals Abundant Tumor-Specific Transcripts in Human Cancer

This study analyzes RNA splicing junctions in 34,775 samples to identify 29,051 tumor-specific transcripts linked to cancer stemness, poor prognosis, and immunotherapy targets.

Interplay of RAP2 GTPase and the cytoskeleton in Hippo pathway regulation

This study identifies RAP2 GTPase as a central integrator of cytoskeletal signals in Hippo pathway regulation, showing its role in mediating responses to cytoskeletal changes and its impact on Hippo kinase activity.

Hippo Signaling Modulates Mechano-inflammatory Responses of Chondrocytes

This study shows that Hippo signaling modulates chondrocyte responses to mechanical overload by regulating NF-kappaB-mediated inflammation and matrix degradation.

High-level production of nervonic acid in the oleaginous yeast Yarrowia lipolytica by systematic metabolic engineering

This study engineered Yarrowia lipolytica to overproduce nervonic acid through metabolic pathway modifications, achieving high titers and purity.

Lysosomal calcium loading promotes arrhythmias by potentiating ryanodine receptor release

This study shows lysosomal calcium handling promotes RyR spontaneous release by increasing SR-junction calcium gradient, and blocking lysosomal function reduces arrhythmias.

Mapping the GALNT1 substrate landscape with versatile proteomics tools

This study identifies hundreds of novel GALNT1 substrates using proteomics tools, revealing preferences for Thr residues and Pro at positions +3 and +4, and implicating GALNT1 in diverse biological pathways.

System-wide profiling by proteome integral solubility alteration assay of drug residence times for target characterization

This paper introduces a method to measure drug residence times on targets by analyzing protein solubility changes after drug removal, enabling better target characterization for drug development.

Basic helix-loop-helix pioneer factors interact with the histone octamer to invade nucleosomes and generate nucleosome depleted regions

This study shows how Cbf1's HLH region interacts with histones to slow nucleosome dissociation, enabling chromatin opening.

Plastid-specific RsmD methyltransferase and ribosome maturation factor RimM are crucial for 16S rRNA maturation and proteostasis

This study identifies chloroplast-specific factors AtRsmD and AtRimM essential for 16S rRNA maturation and chloroplast proteostasis in Arabidopsis thaliana.

Transmembrane region dimer structures of Type 1 receptors readily sample alternate configurations: MD simulations using the Martini 3 coarse grained model compared to AlphaFold2 Multimer

This study compares Martini 3 coarse-grained MD simulations of TM receptor dimers with AlphaFold2 Multimer and NMR structures, finding that Martini 3 samples alternate configurations that interconvert.

The cause of on-target point mutations generated by CRISPR-Cas9 treatment in the yeast Xanthophyllomyces dendrorhous

This study identifies on-target point mutations caused by CRISPR-Cas9 in yeast, showing sequence dependence and involvement of NHEJ components.

Insights into the L3 to L4 developmental program through proteomics

This study identifies proteomic changes during the L3 to L4 molt of B. malayi, highlighting key pathways and proteins involved in development and immune evasion.