Ionomycin Ameliorates Hypophosphatasia via Rescuing Alkaline Phosphatase Deficiency-mediated L-type Ca2+ Channel Internalization in Mesenchymal Stem Cells
Y. Jin, B. Li, X. He, Z. Dong, K. Xuan, W. Sun, L. Gao, S. Liu, W. Liu, C. Hu, Y. Zhao, S. Shi
This study shows ionomycin treatment rescues osteoporosis in HPP by restoring Ca2+ influx via ALPL-mediated L-type Ca2+ channel trafficking in BMSCs.
bioRxiv · Feb 8, 2019Cell Biology