L. Gao

Machine learning driven image segmentation and shape clustering of algal microscopic images obtained from various water types

This study applies FastSAM for automated algal cell segmentation and clustering in water samples, showing high accuracy for single cells and varying clustering performance.

Identification and characterization of a synaptic active zone assembly protein

This study identifies Blobby as a novel regulator of presynaptic active zone nanopatterning and shows its role in maintaining Ca2+ channel packing density and synaptic function.

Mechano-regulation of GLP-1 production by Piezo1 in intestinal L cells

This study shows that Piezo1 in intestinal L cells mechanically regulates GLP-1 production, affecting glucose tolerance and diabetes.

ZFAND6 is a subunit of a TRAF2-cIAP E3 ubiquitin ligase complex essential for mitophagy

This study identifies ZFAND6 as a component of a TRAF2-cIAP E3 ubiquitin ligase complex that regulates mitophagy, maintaining mitochondrial homeostasis and influencing immune responses to viral infection.

NPRL2 gene therapy induces effective antitumor immunity in KRAS/STK11 mutant anti-PD1 resistant metastatic non-small cell lung cancer (NSCLC) in a humanized mouse model

This study shows NPRL2 gene therapy reduces lung metastases in KRAS/STK11 mutant NSCLC in humanized mice by enhancing immune cell infiltration and reducing T cell inhibitory signals.

Kilohertz volumetric imaging of in-vivo dynamics using squeezed light field microscopy

This paper introduces squeezed light field microscopy (SLIM), a method for high-speed 3D volumetric imaging, and demonstrates its application in tracking blood cell motion and neural activity in vivo.

Host 5-HT affects Plasmodium transmission in mosquitoes via modulating mosquito mitochondrial homeostasis

This study shows that host 5-HT levels influence Plasmodium transmission in mosquitoes by modulating mitochondrial homeostasis and reactive oxygen species.

DNA sensor ABCF1 phase separates with cccDNA to inhibit HBV replication

This study identifies ABCF1 as a host protein that interacts with cccDNA, forming phase-separated condensates to suppress HBV replication through innate immune activation and transcription inhibition.

Ligand Response of Guanidine-IV riboswitch at Single-molecule Level

This study investigates the conformational dynamics of the guanidine-IV riboswitch using single-molecule techniques, revealing its ligand-response mechanism and transcriptional sensitivity.

Water inside the selectivity filter of a K+ ion channel: structural heterogeneity, picosecond dynamics, and hydrogen-bonding

This study uses 2D IR spectroscopy and simulations to analyze water dynamics and K+ ion behavior in the KcsA channel selectivity filter, revealing structural heterogeneity and distinct reorientation timescales.

Prdm1 Positively Regulates Liver Group 1 ILCs Cancer Immune Surveillance and Preserves Functional Heterogeneity

This study shows Prdm1 regulates liver cNK cells and ILC1s, affecting cancer metastasis and immune communication, with implications for liver cancer immunotherapy.

Population genomic analyses reveal extensive genomic regions within selective sweeps associated with adaptation and demographic history of a wheat fungal pathogen

This study uses population genomic analyses to identify genomic regions under selection and demographic history of the wheat rust pathogen Pst, revealing adaptation mechanisms and population size changes linked to wheat domestication and agriculture.

Novel hepatocellular carcinomas (HCC) Subtype-Specific Biomarkers

The paper identifies 647 prognostic and diagnostic biomarkers for hepatocellular carcinoma (HCC) using transcriptomic data and machine learning, offering potential for improved diagnosis and treatment.

Inhibition of HSP90 distinctively modulates the global phosphoproteome of Leishmania mexicana developmental stages

This study identifies how HSP90 inhibition differentially affects the phosphoproteome of Leishmania mexicana across life cycle stages, revealing distinct molecular responses in promastigotes and amastigotes.

A Citrullus genus super-pangenome reveals extensive variations in wild and cultivated watermelons and sheds light on watermelon evolution and domestication

The paper constructs a Citrullus super-pangenome using genomic data from 547 watermelon accessions to uncover gene variations and insights into watermelon evolution and domestication.

Targeted repression of DNA topoisomerase I by CRISPRi reveals a critical function for it in the Chlamydia trachomatis developmental cycle

This study uses CRISPRi to knock down topA in Chlamydia trachomatis, showing its critical role in developmental cycle and growth.

Tunable image-mapping optical coherence tomography

This paper introduces TIM-OCT, a tunable imaging technique that provides high resolution in either lateral or axial dimensions or across all dimensions, and demonstrates its application on biological samples.

Contact Stiffness Provides a Unified Frame of Reference for Understanding the Effects of Extracellular Matrix Mechanics on Cell Behaviors

The paper introduces contact stiffness as a framework to quantify how ECM mechanics influence cell behaviors, showing its correlation with YAP activity and stem cell differentiation.

Tracing back primed resistance in cancer via sister cells

The paper introduces ReSisTrace, a method to identify pre-resistant cell states in cancer by analyzing sister cells, and validates its use in ovarian cancer models.

Underlying beneficial effects of Rhubarb on constipation-induced inflammation, disorder of gut microbiome and metabolism

This study investigates rhubarb's effects on constipation-induced inflammation, gut microbiome, and metabolism in mice, showing improvements in cytokine balance, microbial diversity, and fatty acid metabolism.

Label-Free Hyperspectral Imaging and Deep-Learning Prediction of Retinal Amyloid β-Protein and Phosphorylated Tau

This paper develops a label-free hyperspectral imaging method combined with deep learning to detect and predict retinal amyloid β-protein and phosphorylated tau in Alzheimer's disease.

Parallel analysis of RNA ends reveals global microRNA-mediated target RNA cleavage in maize

The paper identifies miRNA targets in maize using PARE datasets, revealing tissue-specific cleavage and new miRNA-target pairs involved in seed germination.

Therapeutic neutralizing monoclonal antibody administration protects against lethal viscerotropic Yellow Fever infection

Therapeutic monoclonal antibodies prevent death from YFV infection.

SARS-CoV-2 variant B.1.1.7 caused HLA-A2+ CD8+ T cell epitope mutations for impaired cellular immune response

This study identifies mutations in SARS-CoV-2 variant B.1.1.7 that reduce HLA-A2 restricted CD8+ T cell epitope binding and impair cellular immune responses.

Optogenetic Manipulation of Cell Migration with High Spatiotemporal Resolution Using Lattice Lightsheet Microscopy

This study modifies lattice lightsheet microscopy to enable optogenetic manipulation of cell migration with high spatiotemporal resolution, achieving subcellular control and long-term cell viability.

The Myb family genes in the rice pathogen Magnaporthe oryzae: Finding and deleting more family members involved in pathogenicity

The paper identifies and deletes 19 Myb genes in Magnaporthe oryzae, finds most are expressed during infection, and identifies co-regulated groups with potential roles in pathogenicity.

3-Phosphoinositide-dependent kinase 1 drives acquired resistance to osimertinib

This study identifies PDK1 as a driver of osimertinib resistance in NSCLC, showing its inhibition sensitizes resistant cells and correlates with disease progression.

UG/Abi: a highly diverse family of prokaryotic reverse transcriptases associated with defense functions

The paper systematically analyzes UG and Abi RTs, classifies them into three major classes, and demonstrates their association with defense functions and antiphage roles.

A potent human monoclonal antibody with pan-neutralizing activities directly dislocates S trimer of SARS-CoV-2 through binding both up and down forms of RBD

This study identifies a potent human monoclonal antibody, 35B5, that neutralizes SARS-CoV-2 and its variants by targeting a conserved epitope on the RBD, offering a potential therapeutic and vaccine design strategy.

DDK inhibition disrupts replication leading to mitotic catastrophe in Ewing sarcoma

This study shows that DDK inhibition causes replication stress and mitotic catastrophe in Ewing sarcoma cells, reducing viability and suggesting DDK as a therapeutic target.