Intrinsic self-organization of integrin nanoclusters within focal adhesions is required for cellular mechanotransduction
K. Jain, K. Y. E. Lim, M. P. Sheetz, P. Kanchanawong, R. Changede
The paper shows that integrin nanoclusters self-organize within focal adhesions at an optimal distance to enable mechanotransduction, with cytoplasmic factors like talin and FHOD1 playing key roles.
bioRxiv · Nov 20, 2023 · PreprintCell Biology