R. Changede

Nano-clusters of ligand-activated integrins organize immobile, signalling active, nano-clusters of phosphorylated FAK required for mechanosignalling in focal adhesions

This study shows that nanoclusters of integrins organize phosphorylated FAK nanoclusters in focal adhesions, which are required for mechanosignalling and disassemble in response to inactivation signals.

Intrinsic self-organization of integrin nanoclusters within focal adhesions is required for cellular mechanotransduction

The paper shows that integrin nanoclusters self-organize within focal adhesions at an optimal distance to enable mechanotransduction, with cytoplasmic factors like talin and FHOD1 playing key roles.

Ligand Geometry Controls Adhesion formation via Integrin Clustering

This study shows that two-dimensional ligand geometry is required for adhesion formation on rigid substrates, with integrin clustering and unliganded integrins playing a key role.