IMPDH polymers accommodate both catalytically active and inactive conformations
S. Anthony, A. L. Burrell, M. C. Johnson, K. C. Duong-Ly, K. Yin-Ming, P. Michener, A. Andrews, J. M. Kollman, J. R. Peterson
The paper investigates IMPDH polymerization and finds that polymerized and non-assembled forms have comparable catalytic activity, with substrate and nucleotide availability affecting filament conformation.
bioRxiv · Jun 19, 2017Biochemistry