Deciphering lentiviral Vpr/Vpx determinants required for HUSH and SAMHD1 antagonism highlights the molecular plasticity of these evolutionary conflicts
P. Larrous, C. Garnier, M. Morel, M. M. Martin, K. Zarrouk, S. Maesen, R. Matkovic, A. Cimarelli, L. Etienne, F. Margottin-Goguet
This study identifies viral determinants in Vpr and Vpx proteins that enable antagonism of SAMHD1 and HUSH, revealing molecular plasticity in lentiviral adaptation to host restrictions.
bioRxiv · Mar 7, 2024Microbiology