M. M. Martin

Deciphering lentiviral Vpr/Vpx determinants required for HUSH and SAMHD1 antagonism highlights the molecular plasticity of these evolutionary conflicts

This study identifies viral determinants in Vpr and Vpx proteins that enable antagonism of SAMHD1 and HUSH, revealing molecular plasticity in lentiviral adaptation to host restrictions.

MORC2 restriction factor silences HIV proviral expression

This study identifies MORC2 as a negative regulator of HIV-1 provirus expression, showing it is recruited to the provirus locus and required for HUSH-mediated silencing.

Binding to DCAF1 distinguishes TASOR and SAMHD1 degradation by HIV-2 Vpx

This study identifies how HIV-2 Vpx distinguishes between degrading TASOR and SAMHD1 by interacting with DCAF1, revealing a ternary complex and key Vpx mutants affecting TASOR degradation.