Structural Basis for Selective Proteolysis of ADAM10 Substrates at Membrane-Proximal Sites
C. H. Lipper, E. D. Egan, K.-H. Gabriel, S. C. Blacklow
This study determines the cryo-EM structure of ADAM10-Tspan15 complex, revealing how Tspan15 relieves autoinhibition and positions the active site for membrane-proximal substrate cleavage.
bioRxiv · Oct 22, 2022 · PreprintBiochemistry