Integrin αvβ8 on T cells is responsible for suppression of anti-tumor immunity in multiple syngeneic models and is a promising target for tumor immunotherapy
E. Dodagatta-Marri, H.-Y. Ma, B. Liang, J. Li, D. S. Meyer, K.-H. Sun, X. Ren, B. Zirak, M. D. Rosenblum, M. Headley, L. Pinzas, N. I. Reed, J. S. Del Cid, M. Adoumie, B. C. Hann, , D. Sheppard
This study shows that blocking integrin αvβ8 on T cells enhances anti-tumor immunity in multiple syngeneic models and is effective even when tumor cells do not express the integrin.
bioRxiv · May 14, 2020Cancer Biology