Kai Etheridge

Antibiotic exposure dynamically generates a substantial number of heterogeneous persisters along a spectrum of tolerance

This study quantifies pre-existing and drug-induced persisters using a framework combining kinetic modeling and SDTK assays, revealing antibiotic-specific persistence dynamics and a tolerance spectrum.

Growth-coupled continuous directed evolution by MutaT7 enables efficient and automated enzyme engineering

This paper introduces a continuous directed evolution method called GCCDE that automates enzyme engineering by linking enzyme activity to bacterial growth, demonstrating its effectiveness in improving CelB's low-temperature activity.