Chronic innate immune impairment and ZIKV persistence in the gastrointestinal tract during SIV infection in pigtail macaques
Jennifer Tisoncik-Go, Thomas B. Lewis, Leanne S. Whitmore, Kathleen Voss, Skyler Niemeyer, Jin Dai, Paul Kim, Kai Hubbell, Naoto Iwayama, Chul Y. Ahrens, Solomon Wangari, Robert D. Murnane, Paul T. Edlefsen, Kathryn A. Guerriero, Michael Gale, , Megan A. O’Connor
This study investigates how SIV-induced immunosuppression affects ZIKV replication and persistence in pigtail macaques, finding increased viral persistence and chronic immune activation in the gastrointestinal tract.
Frontiers in Immunology · Mar 4, 2025Peer-reviewedImmunology