Mitochondrial membrane potential regulates nuclear DNA methylation and gene expression through phospholipid remodeling
Mateus Prates Mori, Oswaldo A. Lozoya, Ashley M. Brooks, Carl D. Bortner, Cristina Antonella Nadalutti, Birgitta A. Ryback, Brittany P. Rickard, Marta Overchuk, Imran Rizvi, Tatiana P. Rogasevskaia, Kai Ting Huang, Prottoy Hasan, György Hajnóczky, Janine Hertzog Santos
This study shows that increased mitochondrial membrane potential causes nuclear DNA hypermethylation, which affects gene expression related to mitochondria and lipid metabolism through phospholipid remodeling.
Nature Communications · Apr 29, 2025Peer-reviewedGenomics