Janine Hertzog Santos

This study shows that antiretroviral therapy during pregnancy impairs postpartum cardiac reverse remodeling and may lead to early signs of heart failure with preserved ejection fraction.

This study shows that increased mitochondrial membrane potential causes nuclear DNA hypermethylation, which affects gene expression related to mitochondria and lipid metabolism through phospholipid remodeling.

This study shows that a brain-specific PGC1α isoform mutation causes motor deficits and gene upregulation in female mice, suggesting a role in female-specific transcriptional programs.

This study shows that maternal exposure to rotenone alters DNA methylation and gene expression in offspring, with long-term effects on health and disease.

This study shows that mitochondrial acetyl-CoA reversibly modulates histone acetylation and gene expression in models of mtDNA depletion.