Ashley M. Brooks

This study shows that the APOE4 allele increases microglial vulnerability to arsenite exposure through transcriptional and functional changes.

This study shows that deleting the immune receptor Lag3 in a familial AD mouse model reduces amyloidosis, microgliosis, and behavioral deficits, suggesting Lag3 as a potential therapeutic target for Alzheimer's disease.

This study shows that increased mitochondrial membrane potential causes nuclear DNA hypermethylation, which affects gene expression related to mitochondria and lipid metabolism through phospholipid remodeling.

Benchmarking six long-read RNA-seq protocol-platform combinations and 14 tools across human, mouse, and manatee shows read length and accuracy drive isoform detection, depth drives quantification.