Oswaldo A. Lozoya

This study shows that increased mitochondrial membrane potential causes nuclear DNA hypermethylation, which affects gene expression related to mitochondria and lipid metabolism through phospholipid remodeling.

SALSA is a method that identifies transcriptional profiles from minimal scRNA-seq data, achieving reproducible results with reduced computational and experimental costs.

This study shows that a brain-specific PGC1α isoform mutation causes motor deficits and gene upregulation in female mice, suggesting a role in female-specific transcriptional programs.

This study shows that maternal exposure to rotenone alters DNA methylation and gene expression in offspring, with long-term effects on health and disease.

This study shows that mitochondrial acetyl-CoA reversibly modulates histone acetylation and gene expression in models of mtDNA depletion.