Omics analysis reveals striking effects of progesterone receptor on mitochondria and mitochondria-mediated apoptosis independent of caspases in Breast Cancer cells
Qian Yee Woo, Pheck Khee Lau, Bernett Lee Teck Kwong, Nataša Bajalović, Shi Hao Lee, Kye Siong Leong, Kai Yee Pow, Simra Hanan, Wei Meng, Soak Kuan Lai, Valerie C. L. Lin
This study uses omics analysis to show that PR agonist R5020 induces anti-proliferative and proapoptotic effects in breast cancer cells through mitochondrial pathways independent of caspases.
bioRxiv · Mar 6, 2025 · PreprintCancer Biology