Pheck Khee Lau

Methylation mimic mutations of progesterone receptor AF1 impair gene-specific regulation through stabilized chromatin interactions

This study shows that methylation mimic mutations in PR AF1 alter gene-specific regulation by affecting chromatin interactions and coregulator binding in breast cancer cells.

Impact of Choline intake during pregnancy on maternal cognition and hippocampal gene signature in old age

This study shows that choline supplementation during pregnancy improves cognitive health in mice during pregnancy and in old age, with lasting effects on hippocampal gene signatures.

Omics analysis reveals striking effects of progesterone receptor on mitochondria and mitochondria-mediated apoptosis independent of caspases in Breast Cancer cells

This study uses omics analysis to show that PR agonist R5020 induces anti-proliferative and proapoptotic effects in breast cancer cells through mitochondrial pathways independent of caspases.