Author

Soak Kuan Lai

Nanyang Technological University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Boon Huan TaniD· 2 shared Benjamin LebeauiD· 1 shared Bernett Lee Teck Kwong· 1 shared C Soh· 1 shared Cheng-Gee KohiD· 1 shared Conrad En-Zuo Chan· 1 shared HY LiiD· 1 shared Jessie Yong Xing WooniD· 1 shared

Activity by Year

2024-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersMicrobiology

Boon Huan TanORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

ILF2 blockade suppresses helicase-mediated R-loop resolution to induce lethality in homologous recombination-deficient cancers

Yi Chieh Lim, Soak Kuan Lai, Ru Yang, Yong Kang Chua, Rémi Patouret, Vaishnervi Manoj, C Soh, Benjamin Lebeau, Ning Cham, Wei Meng, Sze Keong Tey, Szu Ling Yeap, Songjing Zhang, Jessie Yong Xing Woon, Zahin Mohd Ali, , HY Li

This study identifies NYH0002 as a compound that blocks ILF2, leading to DNA breaks and lethality in cancers with specific genetic profiles.

bioRxiv · May 21, 2025 · PreprintCancer Biology

Omics analysis reveals striking effects of progesterone receptor on mitochondria and mitochondria-mediated apoptosis independent of caspases in Breast Cancer cells

Qian Yee Woo, Pheck Khee Lau, Bernett Lee Teck Kwong, Nataša Bajalović, Shi Hao Lee, Kye Siong Leong, Kai Yee Pow, Simra Hanan, Wei Meng, Soak Kuan Lai, Valerie C. L. Lin

This study uses omics analysis to show that PR agonist R5020 induces anti-proliferative and proapoptotic effects in breast cancer cells through mitochondrial pathways independent of caspases.

bioRxiv · Mar 6, 2025 · PreprintCancer Biology

Evidence that the cell glycocalyx envelops respiratory syncytial virus (RSV) particles that form on the surface of RSV-infected human airway cells.

Soak Kuan Lai, Zhi Qi Lee, Ti-Myen Tan, Boon Huan Tan, Richard Joseph Sugrue

The paper shows that the glycocalyx envelops RSV particles as they form on infected cells, with HS and SYND4 on the virus surface.

Virology · Jan 18, 2025Peer-reviewedMicrobiology

Evidence that the SARS-CoV-2 S protein undergoes a conformational change at the Golgi Complex that leads to the formation of virus neutralising antibody binding epitopes in the S1 protein subunit.

Yanjun Wu, Soak Kuan Lai, Conrad En-Zuo Chan, Boon Huan Tan, Richard J. Sugrue

The study shows that SARS-CoV-2 S protein undergoes a conformational change at the Golgi complex, forming epitopes recognized by virus-neutralizing antibodies in the S1 subunit.

Virology · Jul 23, 2024Peer-reviewedMicrobiology