Shi Hao Lee

Methylation mimic mutations of progesterone receptor AF1 impair gene-specific regulation through stabilized chromatin interactions

This study shows that methylation mimic mutations in PR AF1 alter gene-specific regulation by affecting chromatin interactions and coregulator binding in breast cancer cells.

Omics analysis reveals striking effects of progesterone receptor on mitochondria and mitochondria-mediated apoptosis independent of caspases in Breast Cancer cells

This study uses omics analysis to show that PR agonist R5020 induces anti-proliferative and proapoptotic effects in breast cancer cells through mitochondrial pathways independent of caspases.