Circular RNA vaccine performance is determined by RNA quality and epitranscriptomic tuning rather than innate activation
Abby L. Martin, Jessica Cotterell, Kaitlin H. Buick, Thomas W. Bird, Joanna Kuang, Olga Rose Palmer, Ngarangi C. Mason, Lydia G. White, Sarah L. Draper, Amy J. Foster, Gavin F. Painter, Isabelle Montgomerie, Tifany Oulavallickal, Wayne M. Patrick, Lisa M. Connor
This study shows that circRNA vaccine performance depends on RNA quality and epitranscriptomic modifications rather than innate immune activation.
bioRxiv · Jun 15, 2026 · PreprintImmunology