ImmunologyProceedings of the National Academy of SciencesPeer-reviewed
Engineering antigenic breadth against SARS-CoV-2 by pairing divergent RBDs within a single mRNA immunogen
Isabelle Montgomerie, Rebecca E. McKenzie, Olga Rose Palmer…·Lisa M. Connor
This paper designs an mRNA vaccine with fused SARS-CoV-2 RBDs from different variants to elicit cross-reactive antibodies without extensive somatic hypermutation.
DOI 10.1073/pnas.2602574123