Gavin F. Painter

Engineering antigenic breadth against SARS-CoV-2 by pairing divergent RBDs within a single mRNA immunogen

This paper designs an mRNA vaccine with fused SARS-CoV-2 RBDs from different variants to elicit cross-reactive antibodies without extensive somatic hypermutation.

Circular RNA vaccine performance is determined by RNA quality and epitranscriptomic tuning rather than innate activation

This study shows that circRNA vaccine performance depends on RNA quality and epitranscriptomic modifications rather than innate immune activation.

Optimization of a liver Trm cell-inducing mRNA vaccine by reduction of type I interferon response

This study optimizes an mRNA vaccine to enhance liver Trm cell induction by reducing type I interferon responses through improved manufacturing.

Temporal expression of liver-stage malaria antigens shapes vaccine efficacy

The paper identifies temporal expression patterns of liver-stage malaria antigens and shows that combining antigens with different temporal profiles improves vaccine efficacy.