The Escherichia coli Radical SAM Enzyme YhcC Replaces MnmC in mnm5s2U tRNA Modification During Anaerobic Growth
Kaleb Boswinkle, Paige N. Roehling, Colbie Reed, Jasmine Marakorn, Thomas Carell, Agnieszka Dziergowska, Patricia C. Dos Santos, Jeffrey S. Mugridge, Valérie de Crécy‐Lagard
This study identifies YhcC as an anaerobic alternative to MnmC for demodifying cmnm5s2U to nm5s2U in E. coli tRNA.
bioRxiv · Sep 9, 2026 · PreprintBiochemistry