Wen Zhu

The paper characterizes human TBCK as a class I pseudokinase through biochemical and biophysical analysis, revealing its catalytically inactive nature and structural features.

This study investigates how a specific mutation in the ASNS gene impairs enzyme function by disrupting conformational dynamics, using biochemical, cryo-EM, and molecular dynamics approaches.

This study characterizes McHemW, a heme-binding radical SAM enzyme in Moraxella catarrhalis, showing it binds heme and contains an active [4Fe-4S] cluster, suggesting a role in heme transport.

The paper describes how ASX-173 inhibits asparagine synthetase, induces the integrated stress response, and reduces cell growth in HEK-293A cells.

The paper uses 3DVA and MD simulations to reveal that Arg-142 in ASNS acts as a gate controlling ammonia transport through an intramolecular tunnel.

The paper determines the X-ray crystal structure of human ASNS and builds a computational model of the enzyme-inhibitor complex to understand specificity.