Cell fixation improves performance of in situ crosslinking mass spectrometry while preserving cellular ultrastructure
Andrew R. M. Michael, B.C. do Amaral, Kallie L. Ball, Kristen H. Eiriksson, David C. Schriemer
This study introduces a formaldehyde-based fixation method that improves in situ XL-MS performance while preserving cellular ultrastructure in human A549 cells.
Nature Communications · Oct 2, 2024Peer-reviewedBiochemistry