David C. Schriemer

Nuclear body assembly by a viral repeat RNA promotes Kaposi's sarcoma-associated herpesvirus gene expression

The paper shows that Kaposin, a viral lncRNA, remodels nuclear speckles to enhance KSHV gene expression by interacting with repetitive elements.

Microbiome-derived hydroxyphenyl propanoates enhance antitumour immunity by potentiating gasdermin D activity in tumour-associated myeloid cells

This study identifies microbiome-derived hydroxyphenyl propanoates (HPPs) that enhance antitumour immunity by boosting gasdermin D activity in myeloid cells, improving immune checkpoint therapy outcomes in mice and correlating with better responses in human melanoma patients.

Signal Attrition in Whole Cell Crosslinking Mass Spectrometry

The paper identifies signal attrition in XL-MS as the main cause of poor interactome sampling, not low crosslink yield, and highlights issues with signal splitting and database search tools.

Click-linking: a cell-compatible protein crosslinking method based on click chemistry

The paper introduces a novel crosslinking method using click chemistry to enhance XL-MS sampling depth and detect more protein-protein interactions.

A community audit of error control in crosslinking mass spectrometry

The paper audits error control in twelve crosslinking mass spectrometry pipelines using ground-truth designs, finding some pipelines exceed false discovery rates by up to 29-fold.

Recommendations for Automating Hydrogen/Deuterium Exchange Mass Spectrometry Measurements using Data-Independent Acquisition Methods

The paper demonstrates how data-independent acquisition methods can automate hydrogen/deuterium exchange mass spectrometry measurements with improved precision and throughput.

Cell fixation improves performance of in situ crosslinking mass spectrometry while preserving cellular ultrastructure

This study introduces a formaldehyde-based fixation method that improves in situ XL-MS performance while preserving cellular ultrastructure in human A549 cells.

mosaicMPI: a framework for modular data integration across cohorts and -omics modalities

mosaicMPI integrates multi-omics data across cohorts to reveal biological themes and enable rapid mapping of new datasets.

High sensitivity proteome-scale search for crosslinked peptides using CRIMP 2.0

The paper introduces an upgraded CRIMP tool for detecting crosslinked peptides in XL-MS data, showing improved sensitivity and resolution of protein interactions.

Cross-linking/Mass Spectrometry: A Community-Wide, Comparative Study Towards Establishing Best Practice Guidelines

This paper summarizes current XL-MS practices, compares strategies, and proposes common protocols to establish best practice guidelines for accurate and reproducible results.