Author

B.C. do Amaral

University of CalgaryORCID 0000-0002-8056-8565Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:protein folding & dynamics· 2 Research Focus:benchmarking· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

David C. SchriemeriD· 3 shared Andrew R. M. MichaeliD· 2 shared Albert J.R. Heck· 1 shared Andrew KelleriD· 1 shared Claudio IacobucciiD· 1 shared D. Alex CrowderiD· 1 shared David D. ShteynbergiD· 1 shared Diogo Borges LimaiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersBiochemistry

David C. SchriemerORCID

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Author profile →

3 papers

Recent·Most cited

Signal Attrition in Whole Cell Crosslinking Mass Spectrometry

B.C. do Amaral, Nicholas I. Brodie, Andrew R. M. Michael, D. Alex Crowder, Pauline Douglas, Morgan F. Khan, David C. Schriemer

The paper identifies signal attrition in XL-MS as the main cause of poor interactome sampling, not low crosslink yield, and highlights issues with signal splitting and database search tools.

Analytical Chemistry · Jan 2, 2026Peer-reviewedBiochemistry

A community audit of error control in crosslinking mass spectrometry

Lutz Fischer, B.C. do Amaral, Micha Johannes Birklbauer, James E. Bruce, Paulo C. Carvalho, Robert J. Chalkley, Milan Avila Clasen, Viktoria Dorfer, Fabio Cesar Gozzo, Albert J.R. Heck, Michael R. Hoopmann, Claudio Iacobucci, Andrew Keller, Lars Kolbowski, Swantje Lenz, , Juri Rappsilber

The paper audits error control in twelve crosslinking mass spectrometry pipelines using ground-truth designs, finding some pipelines exceed false discovery rates by up to 29-fold.

bioRxiv · Apr 27, 2025 · PreprintBioinformatics

Cell fixation improves performance of in situ crosslinking mass spectrometry while preserving cellular ultrastructure

Andrew R. M. Michael, B.C. do Amaral, Kallie L. Ball, Kristen H. Eiriksson, David C. Schriemer

This study introduces a formaldehyde-based fixation method that improves in situ XL-MS performance while preserving cellular ultrastructure in human A549 cells.

Nature Communications · Oct 2, 2024Peer-reviewedBiochemistry