Free energy spectroscopy reveals the mechanistic landscape of chromatin compaction
Kalven Bonin, Yuchen Wang, Ivan Riveros, Ruo-Wen Chen, Bin Zhang, Ralf A. Bundschuh, Carlos Ernesto Castro, Michael Guy Poirier
This paper introduces Free Energy Spectroscopy (FES) to characterize chromatin compaction by analyzing end-to-end distance and nucleosome stacking interactions, revealing three mechanisms by which linker histones reshape compaction energetics.
Nucleic Acids Research · Jul 14, 2026Peer-reviewedBiophysics